• Chayakrit Krittanawong, Johao Escobar, Hafeez Ul Hassan Virk, Mahboob Alam, Salim Virani, Carl J Lavie, NarayanK M VenkatKMVEmory Global Diabetes Research Center, Woodruff Health Sciences Center and Emory University, Atlanta, Ga., and Raman Sharma.
• Cardiology Division, NYU Langone Health and NYU School of Medicine, New York, NY. Electronic address: Chayakrit.Krittanawong@nyulangone.org.
• Am. J. Med. 2024 Mar 1; 137 (3): 202209202-209.

AbstractLower extremity peripheral artery disease (PAD) is common among patients with several risk factors, such as elderly, smoking, hypertension, and diabetes mellitus. Notably, PAD is associated with a higher risk of cardiovascular complications. Non-invasive interventions are beneficial to improve morbidity and mortality among patients with PAD. Traditional risk factors like smoking, diabetes mellitus, hypertension, and dyslipidemia play a significant role in the development of PAD. Still, additional factors such as mental health, glycemic control, diet, exercise, obesity management, lipid-lowering therapy, and antiplatelet therapy have emerged as important considerations. Managing these factors can help improve outcomes and reduce complications in PAD patients. Antiplatelet therapy with aspirin or clopidogrel is recommended in PAD patients, with clopidogrel showing more significant benefits in symptomatic PAD individuals. Managing several risk factors is crucial for improving outcomes and reducing complications in patients with PAD. Further research is also needed to explore the potential benefits of novel therapies. Ultimately, a comprehensive approach to PAD management is essential for improving morbidity and mortality among patients with this condition.Copyright © 2023 Elsevier Inc. All rights reserved.

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