• Internal medicine · Jul 2024

    Case Reports

    A Case of Autoimmune Hepatitis Complicated by Undiagnosed Factor VII Deficiency: A Pitfall of Coagulopathy.

    • Kotaro Kishimoto, Keisuke Kakisaka, Tamami Abe, Asami Ito, Kenji Yusa, Akiko Suzuki, Kei Endo, Yuichi Yoshida, Takayoshi Oikawa, Akio Miyasaka, Ayaka Sato, Masao Nishiya, Naoki Yanagawa, Hidekatsu Kuroda, and Takayuki Matsumoto.
    • Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Iwate Medical University, Japan.
    • Intern. Med. 2024 Jul 15; 63 (14): 201120142011-2014.

    AbstractProthrombin time (PT) is a key parameter for assessing the severity of liver disease. We present the case of a 37-year-old woman with severe acute liver injury due to autoimmune hepatitis. Although prednisolone drastically improved her hepatocyte function, her PT did not recover to the reference range. A review of her medical records revealed that the patient had normal transaminase levels and prolonged PT 2 years previously. Further examinations of her coagulopathy revealed that she had low factor VII activity, suggesting a diagnosis of factor VII deficiency. Our experience suggests that altered coagulopathy should be considered in cases of liver injury with an extraordinary PT.

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