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- Joe Nemoto, Yukio Takeshita, Shiori Takahashi, Ryota Sato, Michiaki Koga, and Takashi Kanda.
- Department of Neurology and Clinical Neuroscience, Yamaguchi University School of Medicine, Japan.
- Intern. Med. 2024 Jul 1; 63 (13): 193319381933-1938.
AbstractA 73-year-old man was admitted with Cheyne-Stokes respiration and progressive disturbance of consciousness over the course of a month. Cranial magnetic resonance imaging (MRI) revealed signs suggestive of angioedema in the posterior limb of the internal capsule, external capsule, and subcortical white matter. Acute lead encephalopathy was diagnosed based on abnormally high plasma lead levels. After methylprednisolone pulse therapy followed by chelation therapy, the patient fully recovered. In this case, the angioedema with a distinctive magnetic resonance imaging appearance was attributed to the cytotoxic effects of lead on the nervous system, which responded well to methylprednisolone pulse therapy.
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