• Mohamed Aly Mokhles.
• National Research Center, Internal Medicine Department, Center of Excellence for Medical Research, Egypt. Electronic address: mohamad.mokhles@gmail.com.
• Med Clin (Barc). 2024 Mar 8; 162 (5): 231237231-237.

AbstractHepatitis C virus (HCV) infection has been associated as up 40-70% of patients with extrahepatic manifestations (EHM) and 36 different syndromes. These could be attributed to the fact that HCV is lymphotropic, particularly B lymphotropic, and not merely hepatotropic, and could trigger immunological alterations indirectly by exerting a chronic stimulus on the immune system with production of immunoglobulins having rheumatoid activity forming immune complexes and production of cryoglobulins. Cryoglobulinemoa plays a pivotal role in producing most EHM of HCV such as vasculitis, glomerulonephritis, arthritis and neuropathies. Less frequently; while less frequently, the direct viral cytopathic effect could lead to EHMs independent of cryoglobulinemia. The mainstay of treatment of EMH has been antivirals, since interferon era to direct-acting drugs era, with no differences between the two eras, despite the better virological response. Longer evaluation of virological response and clinical investigation with longer follow-ups are necessary.Copyright © 2023 Elsevier España, S.L.U. All rights reserved.

24 keywords...

hide…