• Medicina clinica · Mar 2024

    Observational Study

    Association between reproductive history, breast cancer subtype, and survival in premenopausal women.

    • Marta Bernal-Gómez, Violeta Núñez-Álvarez, Jaime Lluch-Gómez, Carlos de la Torre-Hita, Alicia Campini-Bermejo, Eduardo Perdomo-Zaldívar, Lourdes Rodríguez-Pérez, Julio Calvete-Candenas, Encarnación Benítez-Rodríguez, and José Manuel Baena-Cañada.
    • Servicio de Oncología Médica, Hospital Universitario Puerta del Mar (HUPM), Cádiz, España; Instituto de Investigación e Innovación Biomédica de Cádiz (INIBiCA), Cádiz, España.
    • Med Clin (Barc). 2024 Mar 22; 162 (6): 265272265-272.

    Background And ObjectiveReproductive history influences breast cancer risk. We analysed its association with tumour subtype and survival in premenopausal women.Patients And MethodsRetrospective, observational study of premenopausal women with stage I-III breast carcinoma in the last 20 years. Review of reproductive history, clinical data, and treatments in health records.ResultsIn 661 premenopausal women (32.40% of 1377 total cases), median age was 47 years (19-53), menarche 12 (7-17), first delivery 28 (16-41) and number of deliveries 2 (0-9). One hundred and eleven (18.20%) were nulliparous. Three hundred and fifty-nine (58.80%) used natural lactation, with a median duration of 6 months. Anovulatory drugs were used by 271 (44.40%), with a median duration of 36 months. Associations were found between menarche <10 years and lower risk of luminal subtype (OR: 0.52, 95% CI: 0.28-0.94; P=.03), between menarche >11 years and lower risk of HER2 subtype (OR: 0.50, 95% CI: 0.26-0.97; P=.04) and between first birth >30 years and lower risk of triple negative subtype (OR: 0.40, 95% CI: 0.17-0.93; P=.03). The 20-year overall and disease-free survival probabilities were 0.80 (95% CI: 0.71-0.90) and 0.72 (95% CI: 0.64-0.79) respectively. Patients with ≥1 delivery had better overall survival than nulliparous patients (HR: 0.51, 95% CI: 0.27-0.96, P=.04).ConclusionsThe findings suggest an association between age at menarche and age at first delivery and breast cancer subtype. Nulliparity is associated with worse survival.Copyright © 2023 Elsevier España, S.L.U. All rights reserved.

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