• Feifei Lu, Siqi Jia, Huiyuan Lu, Haonan Zhao, Zhe Li, Yuzheng Zhuge, Fernando Gomes Romeiro, Nahum Mendez-Sanchez, and Xingshun Qi.
• College of Medicine and Biological Information Engineering, Northeastern University, Shenyang, China.
• Curr Med Res Opin. 2024 Feb 1; 40 (2): 303313303-313.

AbstractBudd-Chiari syndrome (BCS) and sinusoidal obstruction syndrome (SOS) are two major vascular disorders of the liver, of which both can cause portal hypertension related complications, but their locations of obstruction are different. BCS refers to the obstruction from the hepatic vein to the junction between the inferior vena cava and right atrium, which is the major etiology of post-sinusoidal portal hypertension; by comparison, SOS is characterized as the obstruction at the level of hepatic sinusoids and terminal venulae, which is a cause of sinusoidal portal hypertension. Both of them can cause hepatic congestion with life-threatening complications, especially acute liver failure and chronic portal hypertension, and share some similar features in terms of imaging and clinical presentations, but they have heterogeneous risk factors, management strategy, and prognosis. Herein, this paper reviews the current evidence and then summarizes the difference between primary BCS and SOS in terms of risk factors, clinical features, diagnosis, and treatment.

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