• Medicina clinica · Feb 2024

    Influence of angiotensin receptor and converting enzyme blockers therapy in the respiratory outcome of COVID-19 hospitalized patients.

    • Felipe B Lima, Francisco Wilker Mustafa Gomes Muniz, Gdayllon C Meneses, Karine C Bezerra, Carolyne N Moreira, André P Aguiar, José Carlos R Nascimento, Tainá Veras de S Freitas, de BruinPedro Felipe CPFCLaboratory of the Biology of Tissue Healing, Ontogeny and Nutrition, Department of Morphology and Institute of Biomedicine, Faculty of Medicine, Federal University of Ceara, Fortaleza, CE, Brazil., Eanes Delgado B Pereira, Elizabeth de F Daher, and Reinaldo B Oriá.
    • Laboratory of the Biology of Tissue Healing, Ontogeny and Nutrition, Department of Morphology and Institute of Biomedicine, Faculty of Medicine, Federal University of Ceara, Fortaleza, CE, Brazil; Department of Anesthesiology, Hospital Geral de Fortaleza (HGF), Fortaleza, CE, Brazil.
    • Med Clin (Barc). 2024 Feb 23; 162 (4): 163169163-169.

    ObjectivesCOVID-19, caused by SARS-CoV-2, has spread around the world since 2019. In severe cases, COVID-19 can lead to hospitalization and death. Systemic arterial hypertension and other comorbidities are associated with serious COVID-19 infection. Literature is unclear whether antihypertensive therapy with angiotensin receptor blockers (ARBs) and angiotensin converting enzyme (ACE) inhibitors affect COVID-19 outcomes. We aim to assess whether ACEI/ARB therapy is a risk factor for worse respiratory outcomes related to COVID-19 in hospitalized patients.MethodsRetrospective study enrolling admitted COVID-19-diagnosed patients by RT-PCR at the Hospital Geral de Fortaleza, Brazil, during 2021. Patient medical records, sociodemographic, and clinical data were analyzed. Chest CT images were analyzed using CAD4COVID-CT/Thirona™ software.ResultsA total of 294 patients took part in the study. A cut-off point of 66% of pulmonary involvement was found by ROC curve, with patients having higher risk of death and intubation and lower 60-day survival. Advanced age (RR 1.025, P=0.001) and intubation (RR 16.747, P<0.001) were significantly associated with a higher risk of death. Advanced age (RR 1.023, P=0.001) and the use of noninvasive ventilation (RR 1.548, P=0.037) were associated with a higher risk of intubation. Lung involvement (>66%) increased the risk of death by almost 2.5-fold (RR 2.439, P<0.001) and by more than 2.3-fold the risk of intubation (RR 2.317, P<0.001).ConclusionsAltogether, our findings suggest that ACEI or ARB therapy does not affect the risk of death and disease course during hospitalization.Copyright © 2023 Elsevier España, S.L.U. All rights reserved.

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