• Internal medicine · Jul 2024

    Case Reports

    Efficacy of Upadacitinib as a Second-line JAK Inhibitor in Ulcerative Colitis: A Case Series.

    • Shuhei Hosomi, Yu Nishida, and Yasuhiro Fujiwara.
    • Department of Gastroenterology, Graduate School of Medicine, Osaka Metropolitan University, Japan.
    • Intern. Med. 2024 Jul 1; 63 (13): 188218851882-1885.

    AbstractUpadacitinib, a recently approved Janus kinase (JAK) inhibitor specific for JAK1, may be a promising candidate in patients with ulcerative colitis (UC) who present no response or intolerance to first-line JAK inhibitors. We assessed the therapeutic impact of upadacitinib on six UC patients who demonstrated an inadequate response or intolerance to tofacitinib or filgotinib. After 2 months of treatment, 5 patients (83.3%) achieved clinical remission, and all patients experienced decreased levels of C-reactive protein. One patient had coronavirus disease 2019 pneumonia and showed a mild increase in transaminase levels. This case series highlights the potential utility of a rotation strategy among JAK inhibitors.

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