• Zoey Petitt, Yesel Trillo Ordonez, Yuveer Kelkar, Muhammad Shakir, Maura Ott, Yash Patel, Chibueze Agwu, Adham M Khalafallah, Alexandria Mullikin, Alan Tang, Jenna Davis, Joseph Mary Ssembatya, Shinbe Choi, Di D Deng, Jennifer Headley, Oscar Obiga, Michael M Haglund, and Anthony T Fuller.
• Division of Global Neurosurgery and Neurology, Duke University, Durham, North Carolina, USA; School of Medicine, Duke University, Durham, North Carolina, USA; Duke Global Health Institute, Duke University, Durham, North Carolina, USA.
• World Neurosurg. 2024 Mar 1; 183: e71e87e71-e87.

BackgroundClinical research is necessary to evaluate neurosurgical interventions, yet clinical trials are conducted less frequently in low- and middle-income countries. Because specific barriers, facilitating factors, and strategies for neurosurgical clinical research in Uganda have not been previously identified, this study evaluated neurosurgical providers' perspectives on clinical research and documentation patterns of neurosurgical variables at Mulago National Referral Hospital.MethodsRetrospective review of 166 neurosurgical patient charts assessed the frequency of documentation of key variables. Twenty-two providers working in neurosurgery participated in 6 focus group discussions with qualitative analysis utilizing the framework method.ResultsChart review showed that primary diagnosis (99.4%), pupil light response (97.6%), and computed tomography scan results (93.3%) were documented for most patients. Cranial nerve exam (61.5%), pupil size (69.9%), and time to neurosurgical intervention (45%) were documented less frequently. On average, Glasgow Coma Scale was documented for 86.6% of days hospitalized, while vital signs were documented for 12.3%. In most focus group discussions, participants identified follow-up, financing, recruitment, time, approval, and sociocultural factors as research barriers. Participants described how the current health workforce facilitates successful research. To improve research capacity, suggested strategies focused on research networks, data collection, leadership, participant recruitment, infrastructure, and implementation.ConclusionsAt Mulago National Referral Hospital, there was variability in the frequency of documentation of neurosurgical variables, which may impact data collection for future studies. While multiple barriers were identified, sociocultural, financing, and time barriers greatly impacted neurosurgical clinical research. Despite that, identified facilitating factors and strategies could be utilized to support neurosurgical research capacity growth.Copyright © 2023. Published by Elsevier Inc.

12 keywords...

hide…