• Wenhui Lu, Xiaoying Li, Wenyi You, and Rui Gong.
• Department of Nephrology and Oncology, The People's Hospital of Yubei District of Chongqing, Chongqing, China.
• Medicine (Baltimore). 2023 Dec 1; 102 (48): e36360e36360.

RationaleRhabdomyolysis can be an uncommon complication of coronavirus disease 2019 (COVID-19) infection. However, the diagnosis of rhabdomyolysis could be easily missed due to its atypical clinical presentations. We present a patient with a history of end-stage renal disease (ESRD) who contracted COVID-19 and subsequently developed rhabdomyolysis. We discuss and share our experience in the management of this patient.Patient ConcernsAn 85-year-old male with ESRD undergoing routine hemodialysis was tested positive for COVID-19. The patient had clinical symptoms of fatigue, muscle pain, and difficulty walking.DiagnosisThe serum creatine kinase (CK) level was markedly elevated to 32,492.9U/L, supporting the diagnosis of rhabdomyolysis. A computed tomography scan revealed muscle injuries throughout the body, confirming the diagnosis.InterventionsThe patient was managed through electrolyte corrections and continuous renal replacement therapy.OutcomesRepeat tests showed decreased levels of serum CK and negative severe acute respiratory syndrome coronavirus 2. His clinical symptoms, including fatigue and muscle pain, had significantly improved.LessonsCOVID-19 infection can cause muscle pain and fatigue, which can mask the symptoms of rhabdomyolysis. A missed diagnosis of rhabdomyolysis can be severe, especially in patients with ESRD. The serum CK level should be tested with clinical suspicion. Appropriate management, including adequate hydration and electrolyte balance, should be provided. Continuous renal replacement therapy should be considered in affected patients with renal insufficiency.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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