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- Chukwuka Elendu, Dependable C Amaechi, Tochi C Elendu, Jennifer O Ibhiedu, Augustina O Torubiri, and Osinachi K Okoye.
- University of California, Santa Cruz, USA.
- Medicine (Baltimore). 2023 Dec 1; 102 (48): e36499e36499.
AbstractConnective tissue disorders, including Marfan syndrome (MS) and Ehlers-Danlos syndrome (EDS), are characterized by genetic mutations affecting connective tissue structural integrity. These disorders significantly elevate the risk of aortic dissection, a life-threatening condition. This comprehensive review delves into the intricate interplay between connective tissue disorders and aortic dissection, shedding light on the clinical features, pathophysiology, genetic underpinnings, diagnostic approaches, clinical management, associated comorbidities, and prognosis, mainly focusing on MS and EDS, while also exploring rare connective tissue disorders and forms of cutis laxa contributing to aortic pathology.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.
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