• Wenxin Song, Shishen Sun, Yilong Feng, Liujun Liu, Tianqi Gao, Shaoxiang Xian, and Jie Chen.
• The First Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, China.
• Medicine (Baltimore). 2023 Dec 1; 102 (48): e36313e36313.

BackgroundThis study aimed to investigate the efficacy and safety of baricitinib in patients with severe coronavirus disease 2019 (COVID-19).MethodsDatabases were searched for studies that compared the clinical efficacy and adverse effects of baricitinib with standard therapy for the treatment of severe COVID-19 and clearly reported relevant outcomes published until December 31, 2022. The corresponding data were extracted from these studies. A fixed-effects model was used to calculate the pooled estimates. The study protocol can be accessed at PROSPERO (CRD42023394173).ResultsThe baricitinib group had a significantly lower mortality rate and proportion of patients who received mechanical ventilation than the control group (OR = 0.61, 0.57; P = .008, 0.02; 95% CI 0.42-0.88; 0.35-0.92; I2 = 71% and 86%, respectively). The length of hospital stay and rates of severe adverse events were not significantly different between the 2 groups.ConclusionBaricitinib reduces mortality and mechanical ventilation requirements in patients with severe COVID-19. Therefore, we developed a comprehensive understanding of the role of baricitinib in patients with severe COVID-19.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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