• Junsheng Jiang, Zheng Fan, and Yueyan Mao.
• Department of Pediatrics, Linping Branch of the Second Affiliated Hospital of Zhejiang University, Hangzhou, China.
• Medicine (Baltimore). 2023 Dec 1; 102 (48): e36329e36329.

RationaleMultisystemic inflammatory syndrome is a syndrome of multisystem involvement caused by a novel coronavirus infection that can lead to cardiogenic shock and death in children.Patient ConcernsA 4-year-old girl was diagnosed with multiple organ and multiple system involvement after Kawasaki disease.DiagnosisNovel coronavirus infection-associated multisystem inflammatory syndrome in children was considered.InterventionsThe patients received aspirin, methylprednisolone and gammaglobulin to treat multisystem inflammatory syndrome.OutcomesAfter treatment, the child recovered and was discharged from the hospital.LessonsMultisystem inflammatory syndrome is often mistaken for Kawasaki disease, fortunately, their treatments are similar, the purpose of this case is to remind clinicians of the need for early management of children with multisystem failure following novel coronavirus infection, increase the detection rate, and save the life of the child.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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