• Jingjing Luo, Xinan Wu, and Yiming Liu.
• Department of Clinical Pharmacy, Hefei BOE Hospital, Hefei, P.R. China.
• Medicine (Baltimore). 2023 Dec 1; 102 (48): e36328e36328.

RationaleLinezolid itself is rarely reported to cause blood pressure elevation, and it is rare to report that linezolid causes hypertensive urgency.Patients ConcernsThis case report describes a 38-year-old man who developed acute hypertension after a postoperative foot infection that was treated with linezolid antitherapy. Hypertensive urgency occurred without obvious potential interaction between linezolid and drugs. After receiving appropriate treatment and stopping medication, the patient's blood pressure returned to normal and did not recur.DiagnosesHypertensive crises occurred during the treatment of linezolid.InterventionsAfter stopping linezolid, the patient's blood pressure gradually returned to normal.OutcomesThe patient's blood pressure returned to normal on the 26th day after stopping linezolid, and no abnormal blood pressure was found in the follow-up 2 months after discharge.LessonsLinezolid is rarely reported to cause elevated blood pressure, even though it may occur in the absence of obvious drug interactions. Case reported fewer reasons may be for clinicians statistically insignificant or notice, and hypertensive urgency often lead to clinical risk, should be given enough attention to clinical. Pay attention to blood pressure monitoring during use, when there is abnormal increase in blood pressure, should consider adverse drug reactions, give timely discontinuation and give symptomatic treatment.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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