• Medicine · Dec 2023

    Review

    Is CaMKII friend or foe for cell apoptosis in eye?: A narrative review.

    • Weixing Xu and Hua Liu.
    • School of Graduate, Dalian Medical University, Dalian, China.
    • Medicine (Baltimore). 2023 Dec 1; 102 (48): e36136e36136.

    AbstractCa2+/calmodulin-dependent protein kinase II (CaMKII) controls cell proliferation, differentiation, apoptosis, and other biological processes that have an essential role in eye diseases. However, it seems that previous studies have generated conflicting conclusions about the effect of CaMKII on cell apoptosis. In this review, we explore the positive and potentially deleterious effects of CaMKII on eye cell apoptosis. We can safely conclude that the early elevation of CaMKII could be viewed as a promoter of cell apoptosis. Overexpression of CaMKII by transfection or pretreatment with drugs helped combat cell apoptosis.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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