• Julia Sopena Falco, Julie Steen, and McCormickP AidenPA0000-0002-5994-6023Liver Unit, St. Vincent's University Hospital, Elm Park, Donnybrook, Dublin 4, DO4 T6F4, Ireland. a.mccormick@ucd.ie.University College Dublin (UCD), Dublin, Ireland. a.mccormick@ucd.ie..
• Liver Unit, St. Vincent's University Hospital, Elm Park, Donnybrook, Dublin 4, DO4 T6F4, Ireland.
• Ir J Med Sci. 2024 Jun 1; 193 (3): 125312561253-1256.

UnlabelledSclerosing cholangitis recurs in some patients following liver transplantation. These high-risk patients may provide clues to the pathogenesis of this disease.AimsIn this single-center study, from a high prevalence area, we investigated the incidence of recurrent sclerosing cholangitis following liver transplantation and re-transplantation.MethodsA retrospective cohort study of all patients with primary sclerosing cholangitis transplanted in the Irish National Liver Transplant program between 1993 and 2019.ResultsRecurrent sclerosing cholangitis occurred in 23/112 patients (20.7%). Overall patient survival was similar in the recurrence and non-recurrence groups. Nine patients were re-transplanted for recurrent disease. Patients with recurrence were significantly younger (42.7 +  - 2.5 years vs. 49.3 +  - 1.3 p < 0.05), and colectomy post-transplant was performed more frequently in the recurrence group (6/21 vs. 9/81 p < 0.05). Further recurrence after re-transplantation was identified in 6/9 patients and was identified a shorter time after transplant than the first recurrence (median 41.5 months; range 26-53 vs. median 65.5; range 38: p < 0.05).Discussion/ConclusionRecurrent PSC following liver transplantation is common, particularly in younger patients. It occurs earlier and is more frequent following a second transplant.© 2023. The Author(s), under exclusive licence to Royal Academy of Medicine in Ireland.

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