• Leonard Fonkeng Sama, Sidoine Sadjeu, TchouangueuThibau FlaurantTF0000-0001-5333-706XDepartment of Microbiology, Haematology and Immunology, Faculty of Health and Pharmaceutical Science, P.O. Box 96, University of Dschang, Dschang, Cameroon., Solange Dabou, Georges Ful Kuh, NgouateuOmer BebeOBUniversity of Yaoundé I, Faculty of Science, Department of Animal Biology and Physiology, P.O. Box 812, Yaoundé, Cameroon., and Michel Noubom.
• Department of Biochemistry, University of Dschang, P.O. Box 67, Dschang, Cameroon.
• Int. J. Clin. Pract. 2023 Jan 1; 2023: 59987275998727.

ObjectiveTo determine the prevalence rate of HIV and diabetes among tuberculosis (TB) patients and also the comorbidity rate.DesignCross-sectional study. Setting. This study was carried out at the Tuberculosis Reference Laboratory, Regional Hospital Bamenda, North West Region of Cameroon, from January 2017 to December 2019. Participants. 1115 cases of pulmonary tuberculosis aged ≥14 years (mean 42.5 ± 15.28 years).MethodsSputum samples collected were acid-fast stained and examined macroscopically as well as inoculated for culture. A chest X-ray was performed for further confirmation of TB diagnosis. After the TB diagnosis was done, fasting blood glucose, 2 h-PG test, HbA1c, and biochemical enzymatic tests were performed for the diagnosis of diabetes. Rapid strip test and enzyme-linked immunosorbent assay were used to diagnose HIV infection. Interventions. No intervention was done during the period of study. Outcome Measures. The prevalence of TB/HIV and TB/HIV/DM, signs and symptoms, imaging results, and bacteriology status among TB/HIV, TB/HIV/DM coinfected, and comorbidity cases.ResultsOf 1115 participants, 38.57% had TB/HIV, and 5.83% had TB/HIV/DM. Among TB/HIV/DM cases, 20.39% had a cough for more than 2 weeks [p  <  0.0001; OR (95%CI): 4.866 (3.170-7.404)], and 35.71% had a fever for at least 2 weeks [p  <  0.0001; OR (95%CI): 7.824 (5.336-11.36)]. The majority of TB/HIV/DM patients (77.42%) had chest pain for at least 2 weeks [p  <  0.0001; OR (95%CI): 114.3 (59.78-207.1)]. 7.41%, 14.18%, and 9.09% of TB/HIV/DM, respectively, had chest abnormality, positive smear, and positive culture (p = 0.018). Significant differences were observed between signs and symptoms, imaging results, bacteriology, treatment history for TB cases and those with HIV and/or DM, and those without HIV and/or DM coinfection and comorbidity.ConclusionThis study reports a high prevalence of DM comorbidity and HIV coinfection among active TB patients in the North West Region of Cameroon as well as TB/HIV/DM comorbidity.Copyright © 2023 Leonard Fonkeng Sama et al.

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