• Eric Estève.
• CHR Orléans, hôpital Porte-Madeleine, service de dermatologie, rue Porte-Madeleine, 45032 Orléans cedex 1, France. eric.esteve@chr-orleans.fr
• Presse Med. 2010 Oct 1; 39 (10): 107110751071-5.

AbstractPemphigoid gestationis (PG) is a rare autoimmune bullous dermatosis associated with pregnancy. Its previous designation, herpes gestationis, is obsolete. PG is characterized by a subepidermic separation induced by the presence of peripheral blood autoantibodies against two hemidesmosomal antigens: BPAG1 and BPAG2. Clinical diagnosis is confirmed by histology and positive cutaneous immunofluorescence tests. The most discriminant examination for other pruritic dermatoses of pregnancy is the enzyme-linked immunosorbent assay (Elisa) NC16A BP 180. First-line treatment is local corticosteroid therapy; if local treatment fails, general corticosteroid therapy should be administered. The prognosis is good for mother and child, except that there is a risk of preterm delivery and of moderate fetal growth restriction. Management in a specialized setting is therefore necessary. Recurrence is possible during subsequent pregnancies.Copyright © 2010 Elsevier Masson SAS. All rights reserved.

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