• J Formos Med Assoc · Jun 2011

    Review

    Intracellular defenses against HIV, viral evasion and novel therapeutic approaches.

    • Robert A Lever and Andrew M L Lever.
    • Department of Medicine, Addenbrooke's Hospital, Cambridge, UK.
    • J Formos Med Assoc. 2011 Jun 1; 110 (6): 350362350-62.

    AbstractHuman immunodeficiency virus (HIV), the causative agent of AIDS, is a retrovirus. It is estimated that, while in the cell, it interacts with almost 10% of cellular proteins. Several of these have evolved to protect the cell from infection with retroviruses and are known as "restriction factors". Restriction factors tell us much about how the virus functions and open up new paradigms for exploring novel antiviral therapeutics. This article gives an update on the three best studied restriction factors, their putative mechanisms of action and how the virus has overcome their effects, together with an indication of novel therapeutic approaches based on this knowledge.Copyright © 2011 Formosan Medical Association & Elsevier. Published by Elsevier B.V. All rights reserved.

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