• Samuel J Starke, Marina B Martinez Rivera, Sonya Krishnan, and Maunank Shah.
• Department of Medicine, Johns Hopkins University, Baltimore, MD, USA. sstarke3@jhmi.edu.
• J Gen Intern Med. 2024 May 1; 39 (6): 951959951-959.

BackgroundIn order to eliminate tuberculosis (TB) in the USA, primary care providers must take on an expanded role in the diagnosis and management of latent tuberculosis infection (LTBI). Clinical practice guidelines and recommendations exist for LTBI management, but there is a need for innovative tools to improve medical students' and residents' knowledge of evidence-based practices for LTBI testing and treatment.ObjectiveTo assess the impact of LTBI-ASSIST, a free online decision support aid, as a novel educational tool and mechanism of delivering clinical practice guidelines for medical trainees.DesignA single site, randomized controlled trial of trainees delivered by electronic survey.InterventionsMedical students and Internal Medicine residents at the Johns Hopkins University School of Medicine.ParticipantsParticipants were randomized in 1:1 ratio to receive the US clinical practice guidelines and recommendations for Latent TB management (control arm) or the guidelines plus an introduction to LTBI-ASSIST (LTBI-ASSIST arm) as they completed a case-based knowledge assessment and reported confidence with domains of LTBI care.Main Measures(1) Proportion of questions answered correctly on a case-based knowledge assessment; (2) change in reported confidence with domains of LTBI care.Key ResultsOne hundred and thirty participants completed the knowledge assessment. Those randomized to receive the LTBI-ASSIST Tool performed better on the case-based knowledge assessment with a mean score of 75.9% (95% CI: 70.6-81.1), compared to 57.4% (52.8-62.0) in the group that received the guidelines only (p <0.001). Similarly, the LTBI-ASSIST group reported a higher change in confidence (measured as post-assessment confidence minus pre-assessment confidence), compared to the control group, in six of the seven domains of LTBI care.ConclusionsLTBI-ASSIST can be an effective supplement to existing guidelines in educating medical trainees and helping providers find evidence-based, guideline-supported answers for questions encountered in clinical practice.Trial RegistrationNIH Clinical Trial Registry No. NCT05772065.© 2023. The Author(s), under exclusive licence to Society of General Internal Medicine.

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