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- Yuichi Kawagashira, Haruki Koike, Kazuya Kawabata, Mie Takahashi, Ken Ohyama, Rina Hashimoto, Masahiro Iijima, Masahisa Katsuno, and Gen Sobue.
- Department of Neurology, Nagoya University Graduate School of Medicine, Japan.
- Intern. Med. 2017 Jan 1; 56 (11): 143114341431-1434.
AbstractWe herein report a case of peripheral neuropathy following exposure to large amounts of glyphosate-based herbicide. A 70-year-old man suffered from pain and purpura in the left sole following exposure to glyphosate-based herbicide. Pain and purpura spread to the opposite side and increased in severity. Mild weakness of the lower limbs was also observed. A sural nerve biopsy revealed the infiltration of lymphocytes around small vessels in the epineurium with numerous eosinophils, deposition of hemosiderins and focal axonal degeneration, compatible with findings of vasculitic neuropathy. Glyphosate-based herbicides should be recognized as a causative agent of vasculitic neuropathy.
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