• Am. J. Med. · Aug 2003

    Review

    Function of gastrointestinal smooth muscle: from signaling to contractile proteins.

    • Khalil N Bitar.
    • Department of Pediatrics, University of Michigan Medical School, Ann Arbor, Michigan, USA.
    • Am. J. Med. 2003 Aug 18; 115 Suppl 3A: 15S23S15S-23S.

    AbstractThe action of smooth muscle in the intestinal wall produces tonic contractions that maintain organ dimension against an imposed load such as a bolus of food, as well as forceful contractions that produce muscle shortening to propel the bolus along the gastrointestinal tract. These functions are regulated by intrinsic electrical and mechanical properties of smooth muscle. The complex signaling process that underlies these functions is discussed in this article. We propose a model that describes the facilitation of sustained contraction of smooth muscle cells in the gut.

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