• Abazar Roustazadeh, Mohammad Najafi, Abdollah Amirfarhangi, and Issa Nourmohammadi.
• Biochemistry Department, Tehran University of Medical Sciences, Tehran 141761351, Iran. A-Roustazadeh@razi.tums.ac.ir
• Ann Saudi Med. 2013 Mar 1; 33 (2): 149154149-54.

Background And ObjectivesMatrix Gla protein (MGP) was originally isolated from bone but it is known to be expressed in several tissues including kidney, lung, heart, cartilage and vascular smooth muscle cells (VSMC) of the blood vessel wall. Since it inhibits calcification in subendothelial space of vessels thus, we evaluated the association of rs1800802(T > C) polymorphism and stenosis of the coronary artery.Design And SettingCross-sectional case-control.Subjects And MethodsOne hundred eighty two subjects recruited on the basis of study protocol from who underwent coronary angiography. The controls (n=70) had normal coronary arteries (up to 5% stenosis). The patients (n=112) subdivided into three subgroups; single-vessel disease (SVD), two-vessel disease (2VD) and three-vessel disease (3VD) based on the number of stenosed coronary vessels (at least 50% stenosis). rs1800802 (T > C) polymorphism was determined by PCR-RFLP technique.ResultsGenotype distribution was not significant between control and patient groups. In addition, there were no significant differences between rs1800802 (T > C) frequency and gender (P=.092), and also patient subgroups (one-, two- and three vessel disease) (P=.840).ConclusionWe concluded that rs1800802 (T > C) polymorphism within the MGP promoter is not related to stenosis of the coronary artery.

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