• S. Afr. Med. J. · Nov 2007

    Chronic mucocutaneous candidiasis - an immunological mystery.

    • A R Rabson.
    • Tufts-New England Medical Center, Boston, USA. Arabson@tufts-nemc.org
    • S. Afr. Med. J. 2007 Nov 1; 97 (11 Pt 3): 119011921190-2.

    AbstractChronic mucocutaneous candidiasis (CMC) refers to a group of disorders which have in common recurrent and persistent infections of the skin, nails and mucous membranes by Candida albicans and occasionally other candida species. A proportion of these patients show an associated endocrinopathy as part of the autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) syndrome. Many cases, however, are not associated with endocrinopathy and demonstrate a variety of T-cell or antigen-presenting cell defects leading to abnormal cell-mediated responses to C. albicans.

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