• Luis F Andrade, Parsa Abdi, Amritpal Kooner, Ahmed Monib Eldaboush, Ramneek K Dhami, Nicole Natarelli, and Gil Yosipovitch.
• Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA. Electronic address: luisandrade@med.miami.edu.
• Burns. 2024 Mar 1; 50 (2): 293301293-301.

BackgroundPost-burn pruritus is one of the most common complaints reported by patients with limited evidence for a gold-standard treatment.ObjectiveTo review the literature and assess the efficacy of various interventions in treating post-burn pruritus.MethodsPubMed, MEDLINE, CINAHL, Web of Sciences, Ovid Databases, and ClinicalTrials.Gov were searched. The articles were scored by two assessors for inclusion with a third independent assessor resolving conflicting scores.ResultsThe present systematic review and meta-analysis synthesised findings from a total of nine studies, representing a pool of 323 patients. The standardized mean effect size for the various categories of interventions was: naltrexone at 1.47 (95 % CI of 0.75-2.20, p < 0.0000), coverings at 0.94 (95 % CI of 0.40-1.48, p = 0.006), topical ozonated oil at 2.64 (95 % CI of 1.94-3.34, p < 0.00001), lasers at 2.34 (95 % CI of 1.60-3.09, p < 0.00001), current stimulation at 1.03 (95 % CI of -0.04 to 2.10, p = 0.06), and lemon balm tea at 0.54 (95% CI of 0.12-0.96, p = 0.01).ConclusionsCurrent evidence suggests that current modalities have a statistically significant, but not clinically significant, reduction in pruritus. This review highlights the limited quality of evidence in the literature and the poor quality of reporting among excluded studies.Copyright © 2023 Elsevier Ltd and ISBI. All rights reserved.

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