• Jeanne de La Rochefoucauld, Nadia Anguel, Julien Schmidt, Nicolas Noel, Xavier Monnet, and Olivier Lambotte.
• Université Paris-Saclay, AP-HP, Service de Médecine Interne Immunologie Clinique, Hôpital de Bicêtre, INSERM, CEA, UMR, Le Kremlin Bicêtre 1184, France.
• J Crit Care. 2024 Apr 1; 80: 154498154498.

AbstractSecondary haemophagocytic lymphohistiocytosis (sHLH) proceeds from uncontrolled and inefficient immune activation leading to hyper-inflammation and multi-organ damage. sHLH proceeds from a wide panel of infectious, auto immune and malignant conditions and bears high mortality despite treatment. Literature on sHLH does not mention heart involvement. We sought to describe occurrence of reversible heart dysfunction in the setting of HLH in order to motivate larger prospective studies assessing the causality link between both conditions. We identified 11 cases in our hospital, systematically searched the PubMed database for publications on HLH and heart involvement and reviewed 36 publications with a total of 18 cases. Amongst these 29 cases, 25 presented with myocardial dysfunction and 14 with pericardial effusion. Twenty-six patients required intensive care management, and 14 patients died. This leads us to hypothesize that heart involvement confers worse prognosis to HLH. Formal accountability of HLH in the occurrence of cardiac manifestations is difficult to establish given the numerous differential diagnoses but reversibility of myocardial dysfunction in 14 survivors and results of two necropsies supported it. These data, and the current knowledge on the pathophysiology of both HLH and heart failure lead us to suggest that such a link may exist.Copyright © 2023 Elsevier Inc. All rights reserved.

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