• Ying-Ying Chen, Shun-Chen Huang, Chien-Ting Pan, Kang-Yung Peng, Liang-Yu Lin, Chieh-Kai Chan, and Chia-Tung Shun.
• Division of Nephrology, Department of Internal Medicine, MacKay Memorial Hospital, Taipei, Taiwan; Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Medicine, Mackay Medical College, Taipei, Taiwan.
• J Formos Med Assoc. 2024 Mar 1; 123 Suppl 2: S135S140S135-S140.

AbstractUnilateral primary aldosteronism is thought to be a surgically curable disease, and unilateral adrenalectomy is the mainstay treatment. The Primary Aldosteronism Surgical Outcome (PASO) consensus was developed to assess clinical and biochemical outcomes to standardize the classification of surgical outcomes. However, fewer than half of patients are cured of hypertension after adrenalectomy; therefore, preoperative patient counseling and evaluation might be necessary. Moreover, current studies show that genetic mutations and histopathology classification are associated with the treatment outcome. The Task Force of Taiwan PA recommends using a specific scoring system, including the PASO score and nomogram-based preoperative score, to predict the clinical outcome before adrenalectomy. Herein, we discuss the associations of current histopathological classification and specific somatic gene mutations with clinical outcomes after surgery.Copyright © 2024 Formosan Medical Association. Published by Elsevier B.V. All rights reserved.

14 keywords...

hide…