• J. Korean Med. Sci. · Dec 2023

    Case Reports

    Eosinophilic Granulomatosis With Polyangiitis Following COVID-19 Vaccination: A Case Report.

    • Yu-Kyoung Hwang, Hui-Hwan Kwak, Jeong-Eun Yun, Sae-Hoon Kim, and Yoon-Seok Chang.
    • Division of Allergy and Clinical Immunology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
    • J. Korean Med. Sci. 2023 Dec 11; 38 (48): e382e382.

    AbstractThe current emergence of the coronavirus disease 2019 (COVID-19) pandemic and the possible side effects of COVID-19 mRNA vaccination remain worrisome. Few cases of vaccination-related side effects, such as vasculitis, have been reported. Eosinophilic granulomatosis with polyangiitis (EGPA), also known as Churg-Strauss syndrome, is a type of vasculitis characterized by the histological richness of eosinophils, asthma, polyneuropathy, sinusitis, and skin or lung involvement. Here, we report the first case of new onset EGPA following COVID-19 vaccination in Korea. A 71-year old woman developed a skin rash and presented with progressive weakness of the upper and lower extremities after the BNT162b2 vaccination (Pfizer-BioNTech). She was diagnosed with EGPA and her symptoms improved after systemic steroid and immunosuppressant therapy. Although it is very rare, clinicians should be aware that EGPA may occur after COVID-19 vaccination.© 2023 The Korean Academy of Medical Sciences.

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