• Zenona Kalveniene, Arūnas Savickas, Liudvinas Svambaris, Vitalis Briedis, and Domininkas Bernatonis.
• Kauno medicinos universiteto Vaistu technologijos ir farmacijos organizavimo katedra, A. Mickeviciaus 9, 3000 Kaunas. vtfo@kmu.lt
• Medicina (Kaunas). 2002 Jan 1; 38 (10): 100910131009-13.

AbstractThe article deals with the production of the complex tincture of Hyperici herba 80.0 g, Cinnamomi cortex 20.0 g, Rosmarini folium 20.0 g, Lavandulae flos 20.0 g, Zingiberis rhizoma 60.0 g and the selection of an extracting liquid phase, and the choice of extraction method. The experimentally determined optimal conditions for tincture preparation were as follows: concentration of ethanol--70% (V/V), the particle size of the leaves, herb, flowers--2.0-3.0 mm, for the bark and the roots--0.3-0.5 mm, the extraction method--percolation. The quality of the tincture was evaluated by analyzing the sum of flavonoids (recalculated into equivalent amount of rutin), dry residue, the concentration of ethanol, density of the extractive preparation, and microbial contamination. Also the overall appearance was checked, the identification of flavonoids was performed by color reactions and high-pressure liquid chromatography.

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