• Nimrod Nachmias, Yaakov Landman, Yehuda L Danon, and Yael Levy.
• Kipper Institute of Immunology, Schneider Children's Medical Center of Israel, Petah Tikva, Israel.
• Isr Med Assoc J. 2010 Nov 1; 12 (11): 684686684-6.

UnlabelledB ACKGROUND:Feeding neonates with humanized milk formula in maternity hospitals may increase the prevalence of milk allergy in infants. However, prospective studies of the possible allergenic effect of very early soy-based formula feeding are lacking.ObjectivesTo assess the prevalence of soy allergy in infants fed soy-based formula in the first 3 days of life.MethodsThe study group included 982 healthy full-term infants born within a 7 month period at a hospital that routinely uses soy-based formula to supplement breastfeeding. In-hospital feeding was recorded and the parents were interviewed once monthly over the next 6 months regarding feeding practices and clinical symptoms suggesting soy allergy in the infant.ResultsNinety-nine percent of the infants received soy-based formula supplement in hospital, and 33%-42% at home. No cases of immediate allergic reaction to soy or soy-induced enterocolitis were reported.ConclusionsThe use of soy-based formula in the early neonatal period does not apparently increase the prevalence of soy allergy in infants followed for the next 6 months.

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