• Belkiz Uyar, Oya Nermin Sivrikoz, Ugur Ozdemir, Teslima Dasbasi, and Handan Sacar.
• Department of Dermatology, Faculty of Medicine, Sifa University, Izmir, Turkey.
• Clinics (Sao Paulo). 2014 Jan 1; 69 (12): 854861854-61.

ObjectivesThe purpose of this study was to analyze the effects of soybean extracts obtained using different extraction methods on the skin of female rats.MethodA total of 64 female Sprague-Dawley rats were divided into 8 equal groups. Various extracts were administered to the female rats by oral gavage for one month. The groups comprised carboxymethyl cellulose-free control, carboxymethyl cellulose-plus control, 100-mg/kg n-hexane extract, 200-mg/kg n-hexane extract, 100-mg/kg ethyl acetate extract, 200-mg/kg ethyl acetate extract, 100-mg/kg ethanol extract and 200-mg/kg ethanol extract groups. The thickness of the collagen layer and the number of estrogen receptor-positive cells were evaluated.ResultsAll the extract-treated groups showed a statistically significant decrease in the number of estrogen receptor-positive cells compared with the control groups. Regarding the thickness of the collagen layer, only the 200-mg/kg ethyl acetate extract-treated group showed a significant increase compared with the control groups (p<0.05).ConclusionsOur data suggest that oral intake of three different total soybean extracts might have positive estrogenic effects on the skin and that only a high-dose ethyl acetate extract can increase the expression of collagen, which may prove to be beneficial for postmenopausal facial skin.

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