• Trong P Nguyen, Ishu Kant, Alec Cartagena, and Jung H Kim.
• Department of Anesthesia, Perioperative and Pain Medicine, Mount Sinai West-Morningside Hospitals, New York City, New York, USA.
• Pain Pract. 2024 Apr 1; 24 (4): 670672670-672.

BackgroundThis case report describes a rare instance of drug-induced aseptic meningitis after an interlaminar lumbar epidural steroid injection.Case PresentationA 74 year-old female patient presented to the ED post-procedure day three after an L4-L5 interlaminar lumbar epidural steroid injection with fever, nausea, and vomiting. The patient had previously undergone numerous lumbar epidurals without complications and used identical medications, which included 1% lidocaine, iohexol contrast, methylprednisolone (Depo-medrol), and normal saline. Pertinent labs included a WBC of 15,000 cells/μL. Lumbar MRI revealed L4-S1 aseptic arachnoiditis. Two bone scans with Gallium and T-99 confirmed no infectious process. The patient then had a second admission months later with similar presenting symptoms and hospital course after repeating the lumbar epidural steroid injection. Lumbar MRI and CSF studies confirmed aseptic meningitis.ConclusionThis patient's repeated admissions from aseptic meningitis were likely caused by irritation of the meningeal layers from a medication used during the procedure.© 2023 World Institute of Pain.

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