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Editorial
Viscoelastic coagulation monitoring for tranexamic acid: personalised antifibrinolytic dosing?
- Kenichi A Tanaka, Sharon M Bouvette, and Amir L Butt.
- Department of Anaesthesiology, University of Oklahoma Health Science Center, Oklahoma City, OK, USA. Electronic address: kenichi-tanaka@ouhsc.edu.
- Br J Anaesth. 2024 Feb 1; 132 (2): 227229227-229.
AbstractEx vivo viscoelastic testing can be used to assess the concentration responses to tranexamic acid in blood samples obtained from pregnant women across the three trimesters and in non-pregnant controls. Minor variations in fibrinolysis across pregnancy suggest a target tranexamic acid blood concentration of 12.5 mg L-1 for complete inhibition of fibrinolysis. Although the data support the potential utility of viscoelastic testing using the ClotPro® TPA test in maintaining therapeutic tranexamic acid concentrations during postpartum haemorrhage, it might obscure potentially crucial endogenous fibrinolysis inhibitor interactions essential to the microcirculation.Copyright © 2023 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.
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