• Delia Colombo, Corinna Rigoni, Alessandra Cantù, Antonello Carnevali, Rossella Filippetti, Tiziana Franco, Alessandra Grassi, Camilla Loi, Annamaria Mazzotta, Ivona Patroi, Beatrice Raone, Marco Andrea Tomassini, Young Dermatologists Italian Network, Angela Amoruso, Marco Pane, and Giovanni Damiani.
• Independent Researcher, Private Practice, Via Livigno 6, 20158 Milan, Italy.
• Medicina (Kaunas). 2023 Nov 27; 59 (12).

AbstractThe role of the skin-gut axis in atopic dermatitis (AD) remains a subject of debate, limiting non-pharmacological interventions such as probiotics and prebiotics. To improve understanding of their potential as a monotherapy for stable mild cases, we conducted a real-life, multicenter, retrospective observational study in Italy. We administered three selected bacteria (Bifidobacterium animalis subsp. lactis BS01, Lactiplantibacillus plantarum LP14, and Lacticaseibacillus rhamnosus LR05) orally to patients with mild atopic dermatitis without a placebo control group, following up for 12 weeks. Clinical assessments using the Scoring Atopic Dermatitis (SCORAD), Eczema Area and Severity Index (EASI), and Three-Item Severity (TIS) score were conducted on 144 enrolled patients (average age: 25.1 ± 17.6 years). Notably, both pruritus and AD-related lesions (erythema, edema/papules, excoriation) exhibited significant clinical and statistical improvement (p < 0.001) after 12 weeks of exclusive probiotic and prebiotic use. These preliminary results suggest a potential link between the skin-gut microbiome and support the rationale for using specific probiotics and prebiotics in mild AD, even for maintenance, to reduce flares and dysbiosis.

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