• BektaşoğluPınar KuruPKDepartment of Neurosurgery, University of Health Sciences, Fatih Sultan Mehmet Education and Research Hospital, Istanbul, Turkey. Electronic address: drpinarkuru@gmail.com., Adnan Somay, Jülide Hazneci, Ali Borekci, and Bora Gürer.
• Department of Neurosurgery, University of Health Sciences, Fatih Sultan Mehmet Education and Research Hospital, Istanbul, Turkey. Electronic address: drpinarkuru@gmail.com.
• World Neurosurg. 2024 Mar 1; 183: e395e400e395-e400.

BackgroundLaminectomy is a widely employed surgical procedure for the treatment of spinal stenosis, but it may lead to epidural fibrosis (EF) and failed back surgery syndrome. Cinnamaldehyde, a phenylpropanoid found in cinnamon, has demonstrated antioxidant and anti-inflammatory properties. In the present study, we hypothesized that topical application and systemic administration of cinnamaldehyde could be helpful in the prevention of EF in a rat laminectomy model.MethodsThe rats were randomly assigned to control, local, and systemic Tween-80 and local and systemic cinnamaldehyde experimental groups (n = 6, per group). In the control group, just laminectomy was performed. In local treatment groups, applications were done just after the laminectomy onto dura. In systemic treatment groups, intraperitoneal administrations were performed following skin suturing. The degree of epidural fibrosis was evaluated macroscopically and histopathologically 4 weeks later.ResultsMacroscopic assessment revealed decreased EF with both topical and systemic cinnamaldehyde application, whereas microscopic examination results were not significant.ConclusionsOur findings provide the first experimental evidence of cinnamaldehyde's potential protective effects against EF.Copyright © 2023 Elsevier Inc. All rights reserved.

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