• Julio C Rotondaro, Celeste Bettaza, Dolores Clifton Goldney, Gabriela Martinez, Leonardo Paz, Carla Gazzi, Santiago González Abbati, Mariano Tarnogol, Silvia Miguel, and Ariel Iungman.
• Servicio de Clínica Médica, Instituto de investigaciones Médicas Alfredo Lanari, Buenos Aires, Argentina. E-mail: rotondarojuliocesar@gmail.com.
• Medicina (B Aires). 2023 Jan 1; 83 (6): 100710121007-1012.

AbstractHypophysitis is a pathology with low incidence and prevalence. Likewise, deep fungal infections in immunocompetent patients also represent a rare phenomenon. Even rarer is the case described below, where these two mentioned elements are combined, namely: pituitary cryptococcoma or granulomatous hypophysitis caused by said pathogen in a host without altered immune response. After research in PubMed, there are limited cases in the medical literature of granulomatous hypophysitis caused by Cryptococcus spp., which simulated a pituitary macroadenoma by clinical and imaging manifestations. We did not find reports in which there is no evidence of involvement of the meningeal tissue. The fungal etiology is scarcely described in the reference guidelines for hypophysitis and we believe that Cryptococcus spp. it should be taken into account in the differential diagnosis of secondary granulomatous hypophysitis since it is a ubiquitous pathogen and the treatment is substantially different from other entities. It becomes more relevant given the current trend towards the use of high-dose systemic glucocorticoids for the treatment of hypophysitis, which could have generated greater damage if the correct diagnosis had not been made.

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