• Minzhi Jiang, Shudian Jiang, Yu Yang, Rucheng Yao, and Mingzheng Hu.
• The First College of Clinical Medical Science, China Three Gorges University, Hubei Yichang, China.
• Medicine (Baltimore). 2023 Dec 15; 102 (50): e36688e36688.

RationalePrimary hepatic lymphoma is a rare extranodal non-Hodgkin lymphoma that is primarily localized in the liver. It predominantly affects elderly males and presents with nonspecific laboratory findings, imaging results, and clinical symptoms, making diagnosis challenging. Histopathological examination serves as the gold standard for diagnosis, and treatment options include chemotherapy or surgical intervention combined with chemotherapy.Patient ConcernsA 50-year-old male patient came to our hospital for treatment after finding a mass in his liver.DiagnosesLaboratory tests and clinical symptoms lack specificity for primary hepatic lymphoma, and imaging findings can be difficult to differentiate. Pathology is the gold standard.OutcomesThe patient was dead.ConclusionA definitive diagnosis primarily relies on histopathological examination, and surgical resection combined with chemotherapy yields better treatment outcomes.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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