• Medicine · Dec 2023

    Review

    Crossmatch assays in transplantation: Physical or virtual?: A review.

    • Yermis Rocha, Andrés Jaramillo, Jorge Neumann, Katrin Hacke, Eduard Palou, and Juan Torres.
    • University of Antioquia, Medellín, Colombia.
    • Medicine (Baltimore). 2023 Dec 15; 102 (50): e36527e36527.

    AbstractThe value of the crossmatch test in assessing pretransplant immunological risk is vital for clinical decisions, ranging from the indication of the transplant to the guidance of induction protocols and treatment with immunosuppressants. The crossmatch tests in transplantation can be physical or virtual, each with its advantages and limitations. Currently, the virtual crossmatch stands out for its sensitivity and specificity compared to the physical tests. Additionally, the virtual crossmatch can be performed in less time, allowing for a reduction in cold ischemia time. It shows a good correlation with the results of physical tests and does not negatively impact graft survival. Proper communication between clinicians and the transplant immunology laboratory will lead to a deeper understanding of each patient's immunological profile, better donor-recipient selection, and improved graft survival.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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