• Jinshuo Tang, Xuemei Wang, Enbo Liu, Zhixin Niu, Jianlin Zuo, Tong Liu, and Hongwei Li.
• Department of Orthopaedics, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China.
• Medicine (Baltimore). 2023 Dec 15; 102 (50): e36674e36674.

RationaleFlorid reactive periostitis (FRP), a rare reactive bone lesion, typically presents in the short tubular bones of the extremities, with infrequent occurrences in the long tubular bones. This report discusses a unique case of FRP in the clavicle, managed through comprehensive lesion debridement and bone grafting, yielding positive results over a 3-year duration.Patient ConcernA 25-year-old male presented with a discernible mass at the left sternal end of the clavicle, discovered incidentally 2 weeks prior. The patient exhibited no clinical signs of inflammation, pain, sinus tract, or suppuration.DiagnosisInitial pathological examination of the local excision suggested benign lesions, although malignancy could not be ruled out. A definitive diagnosis of clavicular FRP was reached post complete lesion resection, with supporting evidence from postoperative pathology, imaging, and clinical symptoms.InterventionThe left clavicle was reconstructed through an open surgical procedure involving total mass removal and ipsilateral extraction of an iliac bone of suitable dimensions. This was implanted into the clavicular bone defect and internally fixed with a plate.OutcomesThree years of consecutive follow-up revealed no recurrence of hyperplasia, absence of mass or tenderness at the left sternal end of the clavicle, and unimpaired function of adjacent joints.LessonsThe primary clinical challenge with FRP is its diagnosis. While pathological diagnosis remains crucial, it is also important to incorporate imaging and clinical symptoms for a comprehensive assessment. Complete mass excision may offer specific benefits in distinguishing FRP from its malignant counterparts.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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