• Huimin Li, Kun Wang, Mengdi Hao, Yin Liu, Xiaoqing Liang, Dajin Yuan, and Lei Ding.
• Department of Oncology, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
• Medicine (Baltimore). 2023 Dec 22; 102 (51): e36590e36590.

AbstractIntestinal microecology is a dominant and complex microecological system in human body. Generally, intestinal microecosystem consists of normal symbiotic flora and its living environment (including intestinal epithelial tissue and intestinal mucosal immune system). Commensal flora is the core component of microecology. Both structures of intestinal mucosa and functions of immune system are essential to maintain homeostasis of intestinal microecosystem. Under normal conditions, intestinal microorganisms and intestinal mucosa coordinate with each other to promote host immunity. When certain factors in the intestine are altered, such as disruption of the intestinal barrier causing dysbiosis of the intestinal flora, the immune system of the host intestinal mucosa makes a series of responses, which leads to the development of intestinal inflammation and promotes colorectal cancer. In this review, to further understand the relationship between intestinal microecology and intestinal diseases, we systematically elaborate the composition of the intestinal mucosal immune system, analyze the relationship between intestinal flora and mucosal immune system, and the role of intestinal flora on intestinal inflammatory diseases and colorectal cancer.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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