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  • J Natl Med Assoc · Dec 2023

    Lp(a) and risk of cardiovascular disease - A review of existing evidence and emerging concepts.

    • Manasa Jasti, Sabrina Islam, Nathan Steele, Kendra Ivy, Willibroad Maimo, and Ijeoma Isiadinso.
    • Division of Cardiology, University of Tennessee Health Science Center/Ascension Saint Thomas, Nashville, TN, United States.
    • J Natl Med Assoc. 2023 Dec 23.

    AbstractCardiovascular disease (CVD) remains the leading cause of death among adults in the United States. There has been significant advancement in the diagnosis and treatment of atherosclerotic cardiovascular disease (ASCVD) and its underlying risk factors. In certain populations, there remains a significant residual risk despite adequate lowering of low-density lipoprotein cholesterol (LDL-C) and control of traditional risk factors. This has led to an interest in research to identify additional risk factors that contribute to atherosclerotic cardiovascular disease. Elevated lipoprotein (a) [Lp(a)] has been identified as an independent risk factor contributing to an increased risk for CVD. There are also ethnic and racial disparities in Lp(a) inheritance that need to be understood. This paper reviews the current literature on lipoprotein a, proposed mechanisms of actions for cardiovascular disease, recommendations for testing, and the current and emerging therapies for lowering Lp(a).Copyright © 2023 National Medical Association. Published by Elsevier Inc. All rights reserved.

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