• Fatemeh Kharazmi, Hajaralsadat Hosseini-Dastgerdi, Ali-Asghar Pourshanazari, and Mehdi Nematbakhsh.
• Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
• J Res Med Sci. 2023 Jan 1; 28: 7676.

AbstractThe denervation or activation of the sympathetic nerve in the kidney can affect renal hemodynamics. The sympathetic nervous system regulates the physiological functions of the kidneys. Stimulation of sympathetic efferent nerves affects various parameters related to renal hemodynamics, including sodium excretion, renin secretion, and renal blood flow (RBF). Hence, renal sympathetic fibers may also play an essential role in regulating systemic vascular resistance and controlling blood pressure. In the absence of renal nerves, the hemodynamics response to stimuli is negligible or absent. The effect of renal sympathetic denervation on RBF is dependent on several factors such as interspecies differences, the basic level of nerve activity in the vessels or local density of adrenergic receptor in the vascular bed. The role of renal denervation has been investigated therapeutically in hypertension and related disorders. Hence, the dynamic impact of renal nerves on RBF enables using RBF dynamic criteria as a marker for renal denervation therapy.Copyright: © 2023 Journal of Research in Medical Sciences.

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