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- K M Saipudinova, T M Uskach, M А Shariya, D V Ustyuzhanin, S V Dobrovolskaya, and S N Tereshchenko.
- Chazov National Medical Research Center of Cardiology.
- Terapevt Arkh. 2023 Sep 25; 95 (9): 776781776-781.
AimTo determine the effect of dapagliflozin therapy on myocardial remodeling and fibrosis according to magnetic resonance imaging (MRI) with contrast in patients with chronic heart failure (CHF) and atrial fibrillation (AF).Materials And MethodsIn the group of 22 patients with a combination of CHF and AF we analyzed the dynamics of remodeling parameters and assessed myocardial fibrosis during 6-month therapy with dapagliflozin according to cardiac MRI with contrast.Results After 6 months of dapagliflozin therapy there was a statistically significant increase in LVEF (27 [23-32]-32 [26.5-36.5] p-0.04) and a tendency to decrease volume and linear dimensions of LV, LP. There was no progression of myocardial fibrosis according to the results of cardiac MRI with contrast in patients with HFrFV and AF.ConclusionsDapagliflozin therapy in patients with HFrEF and AF led to favorable myocardial remodeling changes.
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