Is adamgammadex the brother of sugammadex or the next generation

Br J Anaesth · Jan 2024

Editorial Multicenter Study

Is adamgammadex the brother of sugammadex or the next generation of reversal agent?

Sugammadex is now in widespread use to reverse the neuromuscular blocking effects of rocuronium. Adverse effects from sugammadex are rare, but anaphylactic and cardiovascular reactions to the drug have been reported. ⋯ In a multicentre trial of 310 patients, there was a suggestion of a lower incidence of allergic responses and recurarisation after adamgammadex compared with sugammadex. The clinical implications of this study are discussed in this editorial.

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- Jennifer M Hunter and J Robert Sneyd.
- Department of Aging and Chronic Disease, University of Liverpool, Liverpool, UK. Electronic address: bja@liverpool.ac.uk.
- Br J Anaesth. 2024 Jan 1; 132 (1): 151715-17.
AbstractSugammadex is now in widespread use to reverse the neuromuscular blocking effects of rocuronium. Adverse effects from sugammadex are rare, but anaphylactic and cardiovascular reactions to the drug have been reported. In an attempt to reduce such side-effects, a modified gamma-cyclodextrin, adamgammadex, has been developed. Phase 3 clinical trials suggest that it is slightly less potent than sugammadex and has a non-inferior speed of onset. In a multicentre trial of 310 patients, there was a suggestion of a lower incidence of allergic responses and recurarisation after adamgammadex compared with sugammadex. The clinical implications of this study are discussed in this editorial.Copyright © 2023 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.

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Is adamgammadex the brother of sugammadex or the next generation of reversal agent?

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