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- Naoki Okada, Kenki Saito, Momoko Watanabe, Toshio Ohtani, Kenji Notohara, Hideho Wada, and Yasunori Ueda.
- Department of Hematology/Oncology, Kurashiki Central Hospital, Japan.
- Intern. Med. 2024 Aug 1; 63 (15): 217721822177-2182.
AbstractHuman immunodeficiency virus (HIV)-associated CD8+ T-cell skin infiltrative disease with severe erythroderma has rarely been reported. While HIV-positive patients are prone to develop lymphoma, which is often associated with Epstein-Barr virus, polymorphic lymphoproliferative disorder is rare, accounting for <5% of cases. We herein report a 41-year-old HIV-positive man who presented with a fever, erythroderma, and lymphadenopathy and was diagnosed with the coexistence of both diseases. His condition improved significantly with continued antiretroviral therapy. This case suggests that HIV-induced immunodeficiency is central to the pathogenesis of both entities and that improvement of the immunodeficient state is an effective treatment.
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