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- Yuta Chiba, Rie Kawakita, Katsuya Mitamura, Kenta Takahashi, Tadaki Suzuki, Kazuo Nakamichi, Kenta Suzuki, Asahiro Morishita, Hideki Kobara, Kazushi Deguchi, and Tsutomu Masaki.
- Department of Gastroenterology and Neurology, Graduate School of Medicine and Faculty of Medicine, Kagawa University, Japan.
- Intern. Med. 2024 Aug 15; 63 (16): 232523292325-2329.
AbstractAn 84-year-old Japanese woman presented with left hemiplegia 8 months after completing chemotherapy for mantle cell lymphoma. Brain magnetic resonance imaging (MRI) revealed a hyperintense lesion extending from the right parietal lobe to the left parietal lobe. Compared with these MRI results, 18F-THK5351 PET revealed more extensive accumulation. A brain biopsy showed progressive multifocal leukoencephalopathy (PML). Immunohistochemistry and John Cunningham virus (JCV) DNA-polymerase chain reaction indicated JCV infection. Therefore, a diagnosis of PML was made. 18F-THK5351 PET, indicative of activated astrocytes, clearly depicted PML lesions composed of reactive and atypical astrocytes. 18F-THK5351 PET may capture fresh progressive PML lesions better than MRI.
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