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- Daisuke Sato, Hiroyasu Sato, Toshiyuki Kondo, Ryosuke Igari, Chifumi Iseki, Hikaru Kawahara, Shintaro Amano, Yoya Ono, Akio Kimura, Takayoshi Shimohata, and Yasuyuki Ohta.
- Division of Neurology and Clinical Neuroscience, Department of Internal Medicine III, Yamagata University School of Medicine, Japan.
- Intern. Med. 2024 Aug 1; 63 (15): 218721912187-2191.
AbstractAnti-IgLON5 disease shows various neurological manifestations, of which dysautonomia is one of the major symptoms and is rarely improved by immunotherapy. We herein report a patient with anti-IgLON5 disease who showed several autonomic failures, including vocal cord palsy for four months. The patient presented with cognitive impairments, bulbar symptoms accompanied by myorhythmia in the pharynx and tongue, cerebellar ataxia with tremor, motor neuron symptoms in the limbs, gastrointestinal dysfunction, orthostatic hypotension, non-rapid eye movement sleep disorder on polysomnography, and severe vocal cord palsy. Combined immunotherapy improved his symptoms, including vocal cord palsy, suggesting that combined immunotherapy might improve dysautonomia in anti-IgLON5 disease.
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