• Yang Su, Seidu A Richard, Zhigang Lan, and Yuekang Zhang.
• Department of Neurosurgery, Tibet Chengban Branch of West China Hospital, Sichuan University, Sichuan, P. R. China.
• Medicine (Baltimore). 2024 Jan 5; 103 (1): e36212e36212.

RationaleLhermitte-Duclos disease (LDD), or dysplastic cerebellar gangliocytoma (DCG), is a rare tumor originating from the cerebellar cortex. LDD is a benign neuroglial tumor with uncertain prognosis. Over 200 cases have been reported in the literature mostly in the form of case reports. Thus, we present a spectacular case of LDD with excessive calcification in a female septuagenarian.Patient ConcernsA 72-year-old female presented with progressive dizziness for 8 months and suffered a head and sacrococcygeal region injury 20 days prior to her admission in our neurosurgery department.DiagnosisComputed tomography scan showed a right nonspecific cerebellar mass with striated calcification. Magnetic resonance imaging revealed a right "tiger-striped" alteration of the cerebellar cortex. H&E staining revealed a low grade glial neural tumor which was consistent with the diagnosis of LDD or DCG.InterventionThe lesion was total resected.OutcomesThe patient recovered well and the cerebellar dysfunctional symptoms subsided 3 months after the operation and 2 years follow-up revealed no recurrence of the lesion and no neurological deficits.LesionWe postulate that the calcification of LDD is age-related and the pathogenesis of disease often observed in young adulthood.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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