• Wen En and Yuming Long.
• Department Of Oncology, The first people's hospital of Neijiang, Neijiang, Sichuan, China.
• Medicine (Baltimore). 2024 Jan 5; 103 (1): e36278e36278.

RationaleAlthough the occurrence of combined renal insufficiency among patients with breast cancer is even rarer, it poses a significant challenge in the treatment of these patients. Treating such patients often requires both targeted and endocrine therapies. However, oncologists lack evidence-based guidelines for managing renal function in patients with renal insufficiency.Patients ConcernA 56-year-old menopausal female with a history of renal failure was diagnosed with triple-positive breast cancer and administered endocrine therapy and targeted therapy associated with hemodialysis after surgery.OutcomesUnder the premise of regular dialysis, the patient successfully completed endocrine therapy and targeted therapy for 1 year.DiscussionPatients with advanced triple-positive breast cancer, including those undergoing hemodialysis, require a combination of anti-human epidermal growth factor receptor-2 and endocrine therapies, The side effects of these 2 treatment methods are worth considering in patients with renal insufficiency.ConclusionWe report a case of triple-positive breast cancer in a patient undergoing hemodialysis. There was no difference in the treatment approach between patients with and without normal renal function.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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