• Medicine · Jan 2024

    Randomized Controlled Trial

    Clinical efficacy of rhGM-CSF gel and medical collagen sponge on deep second-degree burns of infants: A randomized clinical trial.

    • Bin Luo, Hai-Tao Sun, Yu-Ting Wang, Jin-Cheng Zhang, Bai Xu, Xian-Zhen Ji, Rui-Zhang Xie, Qiong Liu, and Ru-Jun Chen.
    • Department of Burns, Wenzhou Medical District of NO.906 Hospital of Joint Logistics Support Force of PLA, Wenzhou, China.
    • Medicine (Baltimore). 2024 Jan 5; 103 (1): e36304e36304.

    BackgroundThis study aimed to observe clinical efficacy of recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) gel, medical collagen sponge and rhGM-CSF gel in combination with medical collagen sponge on deep second-degree burns of head, face or neck in infants.MethodsA total of 108 infants with deep second-degree burns on head, face or neck were randomly divided into rhGM-CSF group, medical collagen sponge group, and rhGM-CSF + medical collagen sponge group. The scab dissolving time, healing time, bacterial positive rate and Vancouver scar scale were evaluated and analyzed.ResultsThe data analysis showed that scab dissolving time and healing time were shorter in rhGM-CSF + medical collagen sponge group than that in rhGM-CSF group and medical collagen sponge group, and the difference was statistically significant (P < .05). Bacterial positive rate was lower in rhGM-CSF + medical collagen sponge group than that in rhGM-CSF group and medical collagen sponge group (P < .05). After 3 months, score of Vancouver scar scale (scar thickness, pliability, pigmentation and vascularity) was less in rhGM-CSF + medical collagen sponge group than that in rhGM-CSF group and medical collagen sponge group (P < .05).ConclusionrhGM-CSF gel in combination with medical collagen sponge is significantly effective in treating deep second-degree burns of head, face or neck in infants. This combination is beneficial for infection control, acceleration of scab dissolving and wound healing, and reduction of scar hyperplasia and pigmentation, which is worthy of clinical application and promotion.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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